Search results for " solid lipid nanoparticles"

showing 6 items of 6 documents

Mucoadhesive solid lipid microparticles for controlled release of a corticosteroid in the chronic obstructive pulmonary disease treatment.

2017

Therapeutic efficacy of inhaled drugs is limited by rapid clearance from the site of action due to absorption into systemic circulation or metabolic degradation by alveolar macrophages. Drug delivery systems offer new solutions to clinical problems especially in the treatment of pulmonary diseases. In particular, Solid Lipid Microparticles (SLM) in the range of 3-5 µm are suggested as systems for delivery of therapeutics to the lung as, because of their size, they are able to deposit into secondary bronchi, avoiding systemic absorption typical of alveolar regions. Here, we describe two novel different SLMs prepared with chitosan and alginate for sustained release of fluticasone propionate (…

0301 basic medicineMedicine (miscellaneous)Biocompatible Materials02 engineering and technologyPharmacologymedicine.disease_causeChitosanPulmonary Disease Chronic Obstructivechemistry.chemical_compoundDrug StabilityGlucuronic AcidAdrenal Cortex HormonesMucoadhesive Solid Lipid Nanoparticles (SLMs);Aerodynamic diameter;Chronic obstructive pulmonary disease (COPD)General Materials Sciencechronic obstructive pulmonary disease (COPD)LungChromatography High Pressure LiquidDrug CarriersHexuronic Acidsaerodynamic diameter; chronic obstructive pulmonary disease (COPD); mucoadhesive solid lipid microparticles (SLMs)021001 nanoscience & nanotechnologyLipidsControlled releasemucoadhesive solid lipid microparticles (SLMs)Microspheresmedicine.anatomical_structureDrug deliveryCorticosteroid0210 nano-technologymedicine.drugBiocompatibilityAlginatesCell SurvivalSurface Propertiesmedicine.drug_classBiomedical EngineeringBioengineeringDevelopmentFluticasone propionate03 medical and health sciencesAdministration InhalationmedicineHumansParticle Sizeaerodynamic diameterChitosanLungbusiness.industryEpithelial CellsDrug LiberationOxidative Stress030104 developmental biologychemistryDelayed-Action PreparationsImmunologyMicroscopy Electron ScanningFluticasonebusinessOxidative stress
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SOLID LIPID NANOPARTICLES FOR APPLICATIONS IN GENE THERAPY: A REVIEW OF THE STATE OF THE ART

2010

Importance of the field. Gene therapy represents a new paradigm in the prevention and treatment of many inherited and acquired diseases, including genetic disorders, such as cystic fibrosis, haemophilia and many somatic diseases, such as tumours, neurodegenerative diseases and viral infections, such as AIDS. Areas covered in this review. Among a large array of non-viral transfection agents used for in-vitro applications, cationic SLNs are the topic of this review, being recently proposed as an alternative carrier for DNA delivery, due to many technological advantages such as large-scale production from substances generally recognized as safe, good storage stability and possibility of steam …

Acquired diseasesGenetic enhancementGenetic VectorsPharmaceutical ScienceGene deliveryBiologyBioinformaticsCystic fibrosisGenetic therapyGENE THERAPY SOLID LIPID NANOPARTICLESSolid lipid nanoparticlemedicinegene deliverybusiness.industrynon-viral vectors Read More: http://informahealthcare.com/doi/abs/10.1517/17425240903362410DNAGenetic Therapymedicine.diseasegene therapyLipidsBiotechnologySettore CHIM/09 - Farmaceutico Tecnologico ApplicativoMicroscopy Electron ScanningNanoparticlesbusinesscationic solid lipid nanoparticles
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Surfactant effect on the physicochemical characteristics of cationic solid lipid nanoparticles

2016

Solid lipid nanoparticles (SLNs) may be considered as a new approach for therapeutics for many diseases. In addition to drug delivery, their use as non-viral vectors for gene delivery can be obtained by including cationic lipids, which provide a positive surface potential that favors binding to the nucleic acids as DNA, siRNA, miRNA, etc. In fact, the addition of cationic surfactants is indispensable for obtaining nanoparticles with surface positive charge. In this study, three different cationic lipids (dioctadecyl dimethyl ammonium bromide, cetyltrimethyl ammonium bromide, cetylpyridinium chloride) and Brij 76 as nonionic surfactant were employed to formulate Precirol ATO 5 based cSLN usi…

Ammonium bromideBiocompatibilitysurfactantGreen Fluorescent ProteinsPharmaceutical ScienceCetylpyridinium02 engineering and technologyGene deliveryCationic solid lipid nanoparticleCetylpyridinium chloridePolyethylene GlycolsDiglyceridesSurface-Active Agents03 medical and health scienceschemistry.chemical_compound0302 clinical medicinePulmonary surfactantCationsSolid lipid nanoparticleHumansOrganic chemistrycharacterizationGene deliveryLuciferasesnanocarriersCetrimoniumGene Transfer TechniquesCationic polymerizationDNAGenetic Therapy021001 nanoscience & nanotechnologyLipidsCombinatorial chemistryQuaternary Ammonium Compoundschemistrygene delivery.Settore CHIM/09 - Farmaceutico Tecnologico Applicativo030220 oncology & carcinogenesisNanocarrierDrug deliveryCetrimonium CompoundsNanoparticles0210 nano-technologycationic solid lipid nanoparticlesPlasmids
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Solid lipid nanoparticles containing tamoxifen characterization and in vitro antitumoral activity.

2005

Solid lipid nanoparticles (SLNs) containing tamoxifen, a nons- teroidal antiestrogen used in breast cancer therapy, were prepared by microemulsion and precipitation techniques. Tamoxifen loaded SLNs seem to have dimensional properties useful for parenteral administration, and in vitro plasmatic drug release studies demon- strated that these systems are able to give a prolonged release of the drug in the intact form. Preliminary study of antiproliferative ac- tivity in vitro, carried out on MCF-7 cell line (human breast cancer cells), demonstrated that SLNs, containing tamoxifen showed an antitumoral activity comparable to free drug. The results of char- acterization studies and of in vitro …

DrugOctanolsMaterials scienceTime FactorsAntineoplastic Agents Hormonalmedia_common.quotation_subjectPharmaceutical SciencePharmacologyColloidal Drug Delivery Systems Solid Lipid Nanoparticles (SLNs) TamoxifenBreast cancerDrug StabilityCell Line TumorSolid lipid nanoparticlemedicineHumansParticle Sizeskin and connective tissue diseasesmedia_commonCell ProliferationDrug CarriersWaterGeneral MedicineHydrogen-Ion Concentrationmedicine.diseaseAntiestrogenLipidsIn vitroNanostructuresbody regionsTamoxifenSolubilityDelayed-Action PreparationsCancer cellDrug carrierTamoxifenmedicine.drugDrug delivery
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EMPLOYMENT OF CATIONIC SOLID-LIPID NANOPARTICLES AS RNA CARRIERS

2007

Gene transfer represents an important advance in the treatment of both genetic and acquired diseases. In this article, the suitability of cationically modified solid-lipid nanoparticles (SLN) as a nonviral vector for gene delivery was investigated, in order to obtain stable materials able to condense RNA. Cationic SLN were produced by microemulsion using Compritol ATO 888 as matrix lipid, Pluronic F68 as tenside, and dimethyldioctadecylammonium bromide (DDAB) as cationic lipid. The resulting particles were approximately 100 nm in size and showed a highly positive surface charge (+41 mV) in water. Size and shape were further characterized by scanning electron microscopy (SEM) measurements. M…

MicroinjectionsCell SurvivalBiomedical EngineeringPharmaceutical ScienceNanoparticleBioengineeringNanotechnologyElectrophoretic Mobility Shift AssayPoloxamerGene deliveryTransfectionParacentrotus lividusCationsSolid lipid nanoparticleAnimalsNanotechnologyeducationcationic solid lipid nanoparticles gene deliveryOvumPharmacologyeducation.field_of_studyDrug CarriersbiologyChemistryOrganic ChemistryFatty AcidsCationic polymerizationRNAMembrane ProteinsTransfectionbiology.organism_classificationLipidsQuaternary Ammonium CompoundsSea UrchinsBiophysicsMicroscopy Electron ScanningNanoparticlesRNAEmulsionsDimethyldioctadecylammonium bromideBiotechnology
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Hydrophilic Sponges loaded with Curcumin solid lipid nanoparticles and Metronidazole applied on L-PRF clot to promote tissue regeneration in dentistry

2018

Leukocyte-and platelet-rich fibrin (L-PRF) technology allows for the preparation of strong fibrin membranes enriched with cells (activated platelets, leukocytes, circulating cells) and platelet growth factors [1]. In dentistry, the use of this autologous platelet concentrates such as L-PRF, also in association with Metronidazole (MTR), seems an innovative approach for vestibular bone grafting on the alveolar ridges [2]. In addition, Curcumin (CUR), a natural polyphenol derived from the rhizome of the Curcuma longa, could be effectiveness on tissue regeneration due to its well-known antioxidant and anti-inflammatory properties [3]. The aim of the present work was the development of bioerodib…

Settore MED/28 - Malattie OdontostomatologicheSettore CHIM/09 - Farmaceutico Tecnologico ApplicativoL-PRF solid lipid nanoparticles bioerodible sponges Curcumin Metronidazole.
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